I have MCAS, hyper-mobility Syndrome, dysautonomia and osteoporosis. For the osteoporosis my doctor has me on vitamin D3 and calcium. In the past year my doctor has tried me on two different oral Bisphosphonates, both of them made me have flu like symptoms, the monthly pill had me down for three weeks. The doctor now wants me to get a shot of denosumab (Prolia) that will last for 6 months. I’m quite nervous to try any more treatments as my body reacted so bad to the prior treatments. Has anyone on this forum with mast cell disorders tried denosumab or had positive results with other osteoporosis medications?